| Gene name: | PPARD |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HCAEC |
| Experiment: | SA-β-gal activity assay |
| Description: | The increase in SA-β-gal activity was significantly reduced in the presence of GW501561, a PPARδspecific ligand, demonstrating the involvement of PPARδin the inhibition of Ang II-induced premature senescence. |
| Target gene: | SIRT1 |
| Official symbol(s): | SIRT1 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | RT-PCR//Knockdown//SA-β-gal activity assay |
| Target gene description: | When cells were exposed to 100 nM GW501516, the increase in SIRT1 mRNA was significant at 1 h and reached a maximum at 3 h.Whereas knockdown of SIRT1 by siRNA significantly reversed the effect of GW501516 on both ROS generation and cellular senescence in HCAECs following exposure to Ang II. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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