| Gene name: | TACC3 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MCF-7 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | shRNA-mediated depletion of TACC3 resulted in a strong inhibition of MCF-7 cell proliferation, as evidenced by the progressive accumulation of cells arrested in G1and a decline in bromodeoxyuridine incorporation as a marker for DNA synthesis，Consistently, these cells developed several signs of a senescent phenotype, including a flattened and enlarged morphology and increased expression of senescence-associated βgal activity. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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