| Gene name: | EHF |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF |
| Gene ID: | 26298 |
| Category: | protein coding |
| Phenotype: | Prostate cancer |
| Experimental category: | L |
| PMID: | 17172423 |
| Experiment: | Knockdown//SA-β-gal activity assay |
| Description: | Treatment of MEFs with the EHF-targeting siRNA resulted in decreased EHF, enlargement and flattening of the cells, and positive SA-β-Gal activity，EHF overexpression effectively rescued siEHF-induced senescence and the corresponding SA-β-Gal positivity. |
| Target gene: | P16//P27 |
| Official symbol(s): | P16//P27 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Knockdown//SA-β-gal activity assay |
| Target gene description: | EHF-knockdown cells had increased levels of p16 and p27 expression.The presence of sip27 prevented accumulation of p27 protein and reduced the SA-β-gal –positive population in MEFs and PC-3 cells, compared with controls transfected with siEHF alone. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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