| Gene name: | HDAC1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | WI-38 |
| Experiment: | SA-β-gal activity assay |
| Description: | Young WI-38 cells cultured in the presence of either HDAC inhibitor cells. Untreated proliferating WI-38 cells propagated in parallel had no SA-β-gal activity acquired the perinuclear staining for SA-β-gal activity normally associated with senescen，treatment with butyrate or TSA for 24 hours induced the expression of p21WAF1 in proliferating WI-38 cells. Distinct morphological changes also occurred when WI-38 cells enter replicative senescence. Senescent cells became larger and assumed irregular shapes, while proliferating WI-38 cells formed long，and striated parallel array. |
| Target gene: | P21 |
| Official symbol(s): | P21 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Ttreatment with HDAC inhibitors butyrate or TSA induced p21WAF1 expression in proliferating WI-38 cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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