| Gene name: | PIM1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | 2BS |
| Experiment: | Western blot//Knockdown//SA-β-gal activity assay//MTT assay |
| Description: | Additionally, Pim-1 overexpression increased levels of the senescence-associated protein p16 and decreased levels of the DNA methyltransferase DNMT1, which is known to negatively correlate with senescence.Conversely, HBP1 knockdown attenuated the effect of Pim-1 on the expression of these two genes. HBP1 knockdown also attenuated Pim-1-induced senescence as indicated by SA-β-gal staining and growth arrest in 2BS cells, suggesting that HBP1 also participates in Pim-1-induced premature senescence in normal cells. |
| Target gene: | HBP1 |
| Official symbol(s): | HBP1 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Phosphorylation |
| Target gene experiment: | Western blot |
| Target gene description: | Exogenous Pim-1 increased HBP1 protein levels but had no effect on HBP1 mRNA expression. Moreover, Pim-1 knockdown decreased HBP1 protein levels but had no effect on HBP1 mRNA. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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