| Gene name: | S100A6 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | Compared with control cells treated with scrambled siRNA,S100A6-depleted cells appeared larger and more "fluffy". Analysis showed that these larger, "fluffy" HUVECs exhibited blue staining characteristic of β-galactosidase expression, with a higher incidence of blue cells occurring upon depletion of S100A6. Quantification revealed an increase in β-galactosidase levels of greater than four-fold upon S100A6 depletion. |
| Target gene: | CDK1 |
| Official symbol(s): | CDK1 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Depletion of endothelial S100A6 caused a decrease in both CDK1 and phospho-CDK1 levels in subconfluent HUVECs,Importantly, in HUVECs, depletion of the S100A6 levels by S100A6 siRNA#3 caused a decrease of almost 50% in the levels of CDK1 mRNA. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...