| Gene name: | HRAS |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | As expected, early-passage primary MEFs expressing H-RasV12 and WT KSR1 exhibited characteristics of cellular senescence, such as reduced proliferation in culture and SA β-galactosidase activity, concomitant with the induction of p16INK4a, p15INK4b, and p53 and sustained ERK activity. |
| Target gene: | KSR1 |
| Official symbol(s): | KSR1 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | SA-β-gal activity assay//Western blot |
| Target gene description: | Early-passage primary MEFs expressing H-RasV12 and WT KSR1 exhibited characteristics of cellular senescence, such as reduced proliferation in culture and SA β-galactosidase activity, concomitant with the induction of p16INK4a, p15INK4b, and p53 and sustained ERK activity.However, MEFs expressing H-RasV12 and KSR1.CBM did not undergo proliferation arrest or demonstrate SA β-galactosidase activity, similar to primary MEFs expressing only H-RasV12. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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