| Gene name: | CSNK1A1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Gene ID: | 1452 |
| Category: | protein coding |
| Phenotype: | Colorectal cancer |
| Experimental category: | HL |
| PMID: | 21331045 |
| Experiment: | SA-β-gal activity assay//Western blot//qRT-PCR |
| Description: | Likewise, ablation of Csnk1a1 in MEFs and mRNA depletion of the corresponding gene, CSNK1A1, in human primary fibroblasts (IMR-90 cells) resulted in a persistent DDR and a senescence phenotype. |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53 |
| Pathway experiment: | Western blot//Immunohistochemistry |
| Pathway description: | By contrast, Csnk1a1Dgut mice showed marked p53 expression. Transcriptome analysis revealed that, not only the Wnt cascade, but also the p53 pathway is strongly induced byCsnk1a1 ablation . This was confirmed by monitoring the induction of several specific p53 target genes, including the anti-proliferative gene p21. |
Annotation:
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