| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HDF |
| Gene ID: | 23411 |
| Category: | protein coding |
| Phenotype: | Colorectal cancer |
| Experimental category: | HL |
| PMID: | 22190494 |
| Experiment: | SA-β-gal activity assay |
| Description: | Only in c-MYC immortalized but not in primary HDFs down-regulation of SIRT1 by siRNAs induced a pronounced increase in cell size and senescence-associated β-galactosidase activity at pH 6, two markers of cellular senescence. |
| Target gene: | C-MYC |
| Official symbol(s): | C-MYC |
| R-AG-Target gene: | Inhibition |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | HDFs immortalized by retroviral introduction of constitutive expression of c-MYC (6) showed increased expression of SIRT1 protein. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...