| Gene name: | SIRT6 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HBEC |
| Gene ID: | 51548 |
| Category: | protein coding |
| Phenotype: | Idiopathic pulmonary fibrosis |
| Experimental category: | L |
| PMID: | 21224216 |
| Experiment: | SA-β-gal activity assay |
| Description: | Overexpression of SIRT6 significantly suppressed the percentage of SA-β-gal staining cells after TGF-β1 treatment. In contrast, SIRT6 siRNA dramatically increased the percentage of SA-β-gal staining cells, indicating that TGF-β-induced intrinsic SIRT6 upregulation alone is not sufficient to completely inhibit senescence, but SIRT6 has the ability to antagonize TGF-β-induced cellular senescence in HBEC. |
| Target gene: | TGF-β |
| Official symbol(s): | TGFB1 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | SA-β-gal activity assay |
| Target gene description: | Overexpression of SIRT6 significantly suppressed the percentage of SA-β-gal staining cells after TGF-β1 treatment. In contrast, SIRT6 siRNA dramatically increased the percentage of SA-β-gal staining cells, indicating that TGF-β-induced intrinsic SIRT6 upregulation alone is not sufficient to completely inhibit senescence, but SIRT6 has the ability to antagonize TGF-β-induced cellular senescence in HBEC. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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