| Gene name: | UBE3A |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Human Burkitt Lymphoma cell line derived cell line |
| Gene ID: | 7337 |
| Category: | protein coding |
| Phenotype: | B-cell lymphoma |
| Experimental category: | L |
| PMID: | 22689861 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | Down-regulation of E6AP increased the proportion of cells in G1 with a corresponding decrease of cycling cells , resulting in a reduction in cell proliferation with no impact on cell viability. This effect coincided with a significant number of cells showing hallmarks of senescence . |
| Regulatory pathway: | PML |
| R-AG-Pathway: | Upregulation |
| Official symbol(s): | PML |
| Pathway experiment: | Western blot//Immunofluorescence |
| Pathway description: | Strikingly, E6AP knockdown resulted in restoration of PML expression and formation of PML-NBs in these cells. |
Annotation:
Loading,please wait...