| Gene name: | SRSF3 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Fibroblast |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | The cells transfected with siSRSF3 no. 1 and siSRSF3 no. 2, but not those with a control siRNA (siControl), underwent a senescent growth arrest rapidly (within 7 days) with concomitant induction of the SA-β-gal activity. |
| Target gene: | TP53 |
| Official symbol(s): | TP53 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | RT-PCR//qRT-PCR//Western blot//Knockdown |
| Target gene description: | Knockdown of SRSF3 also increased p53b protein level, reminiscent of its accumulation in replicative senescence. When the alternative splicing patterns of TP53 were examined by conventional RT-PCR and qRT-PCR,mRNA levels of p53b were remarkably upregulated upon SRSF3 knockdown, while the levels of fulllength p53 mRNA were moderately decreased. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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