| Gene name: | GRSF1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | WI-38 |
| Experiment: | Immunofluorescence//Western blot//SA-β-gal activity assay |
| Description: | Immunofluorescence analysis confirmed that GRSF1 levels declined in senescent cells and Western blot analysis further established that GRSF1 levels decreased early in senescence SA-β-gal analysis revealed greater numbers of positive (blue) senescent cells after GRSF1 depletion, supporting the notion that lowering GRSF1 promoted cell senescence. |
| Target gene: | IL-6 |
| Official symbol(s): | IL6 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR//ELISA |
| Target gene description: | The levels of IL6 mRNA and secreted IL6 were significantly higher in GRSF1-silenced WI-38 fibroblasts, as determined by RT-qPCR analysis and AlphaLISA， respectively. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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