| Gene name: | MDH1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HDF |
| Experiment: | Knockdown//SA-β-gal activity assay//Cell morphological analysis |
| Description: | We found that about 60 % of SA-β-Gal-positive cells appeared among MDH1 knockdown cells, but only 10 % among control cells. shMDH1-infected young HDFs also became flattene and enlarged；cell numbers in cultures of MDH1 knockdown HDFs were decreased by about 50 % compared to control cells plated at the same density and cultured for the same duration . |
| Target gene: | SIRT1 |
| Official symbol(s): | SIRT1 |
| R-AG-Target gene: | Inhibition |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//Western blot//RT-PCR |
| Target gene description: | SIRT1 RNA levels were decreased in MDH1 knockdown cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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