| Gene name: | ATF7IP |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | EdU assay//SA-β-gal activity assay//DAPI staining//Knockdown |
| Description: | MCAF1 knockdown severely impaired cell proliferation and reduced incorporation of a thymidine analog EdU;MCAF1 knockdown cells were positive for SA-β-gal activity.DAPI staining showed that approximately 3 % of MCAF1 knockdown cells displayed nuclear foci that resemble SAHF. |
| Regulatory pathway: | RB |
| R-AG-Pathway: | -- |
| Official symbol(s): | retinoblastoma |
| Pathway experiment: | Western blot |
| Pathway description: | We also found that the cdk inhibitors p16 and p21 were upregulated at both mRNA and protein levels, and RB protein was dephosphorylated in MCAF1 knockdown cells. |
Annotation:
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