Browse Detail

Aging Overview

Aging gene

Gene name:

PTEN

Aging type:

Prevent

Aging characteristic:

Tissue type:

Cell name:

MCF-7

Gene ID:

5728

Category:

protein coding

Phenotype:

Aging

Experimental category:

PMID:

30337688

Experiment:

Knockdown//SA-β-Gal activity assay

Description:

The SA-β-Gal positivity of PTEN KO MEFs was dramatically attenuated in Torin1-treated cells compared to Rapa-treated cells.

Regulatory pathway:

P53-P21

R-AG-Pathway:

Official symbol(s):

TP53-CDKN1A

Pathway experiment:

Western blot

Pathway description:

PTEN-depleted MCF7 cells displayed prematurely senescent phenotypes in a p53/p21-dependent manner.

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.