| Gene name: | RRAD |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | NHF |
| Experiment: | Knockdown//SA-β-Gal activity assay |
| Description: | We found that RRAD knockdown increased the ratio of senescent cells in both H2O2- and IR-induced senescence as determined by SA-β-gal staining assay and BrdU incorporation assay. |
| Target gene: | P53//NF-κB |
| Official symbol(s): | P53//NFKB1 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//CHIP-Seq//qRT-PCR |
| Target gene description: | We established p53 knockdown NHFs by a lentiviral based approach for the following functional assay. In OIS, p53 knockdown diminished H-Ras-induced RRAD up-regulation.p53 knockdown also abolished H 2O2-induced RRAD expression.In a published ChIP-Seq data set of IMR-90 cells, we noted that both p53 and NF-κB bind to the RRAD promoter region in adjacent sites. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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