| Gene name: | MORC3 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | WI-38 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | The percentage of SA-β-Gal–positive cells infected with the MORC3-retrovirus vector (51.0±5.1%) was significantly greater than that of controls infected with vector alone (2.3±0.8%). MORC3 expression also strongly induced p16, another senescence marker. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | Activation |
| Subcategory: | Phosphorylation |
| Target gene experiment: | Luciferase reporter assay |
| Target gene description: | FLAG-MORC3 expression enhanced transcriptional activation by endogenous p53 of a reporter containing 12 p53-responsive elements (PG12S) in a dose-dependent manner, but not activation of a reporter containing 14 mutated responsive elements (MG14S). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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